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Chemical technology and biotechnology, chemistry

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Full-time, part-time, correspondence

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№ 0004 Series 90l01 No. 0000004 is valid from 05/29/2012 indefinitely

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Department of proteoma studies and mass spectrometry, department of bioinformatics, department of personalized medicine, scientific laboratories, department of nanoplaysses

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general information

FGBU "IBMH" Ramna conducts medical and biological research in the following areas:
Identification of biomarkers for predicting the risks and early diagnosis of socially significant diseases using post-generic technologies (personalized medicine)
Development of molecular detectors, reagents, algorithms and laboratory protocols to create new methods of medical diagnostics
Search for molecular targets, design and research physiologically active substances, creation of drug transport systems

The staff number is 182 employees, from them researchers - 169 (doctors of sciences - 29, Candidates of sciences - 82).

The cumulative index of Hirsch Institute for 2011 according to Web of Science is 32.

Areas of competence: biochemistry and medical chemistry, transcriptomic, proteomics and metabolomic, nanobiotechnology, cellular and systemic biology, bioinformatics.

The Institute is an educational basis for students of the Medical and Biological Faculty of the Russian National Research Medical University.

Created in 1944 as the Institute of Biological and Medical Chemistry of AMN USSR on the basis of biochemistry departments and organic chemistry All-Union Institute of Experimental Medicine.

The current name has since 1992 in 1944-1948. The institute headed Acad. Academy of Scroll Ya.O. Parnas, in 1949-1989 - Acad. Ramne V.N. Orekhovich. At the Institute worked Acad. A.E. Brownshtein, M.M. Shemyakin, S.E. Severin, N.A. Yudaev and others. Outstanding Russian biochemistry scientists.

Basic studies are related to the study of the structural and functional organization of biological macromolecules, mechanisms of intermolecular recognition during immune reactions, enzyme-substrate interactions, in the reception processes, with the development of new methods of bioinformatics and computer design of drugs, with the creation of funds for the diagnosis and treatment of the most common diseases; A hepatoprotector "Phosphogli" is developed and produced, intended for the treatment of liver diseases of various etiologies, including viral hepatitis (government premium Russian Federation In the field of science and technology (2003) for the creation of a domestic drug "Phosphogli" for the treatment of liver diseases).

The institute has created the first department of proteomal research (2000) and the Center for the Collective Use "Protea of \u200b\u200bMan" (from 2003 to 2010, the Center for the Collective Use of Postgenomous Technology Center), the scientific and practical magazine "Biomedical Chemistry" (Named. Until 2003 - "Issues of Medical Chemistry"). Since 2007, the most rating articles of the Journal "Biomedical Chemistry" go on english language As an app to Biochemistry (Moscow) - Supplement Series B: Biomedical Chemistry.

The Institute is an educational and research base for students and graduate students.

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Fundamental scientific research programs of the Russian Academy of Medical Sciences for 2008-2012:
Study of molecular mechanisms for the development of socially significant diseases using postgenis technologies. (lab diagnostic proteomics)
Development of a systematic approach to the analysis of living objects by combining the methods of genomics, elevation, metabolomic and bioco and cheminformatics with mathematical means of data processing in order to identify molecular targets of drugs. (Lab. Systemic biology and structural and functional design of drugs)
Developing original algorithms and computer programs to establish the relationship "Amino acid sequence - structure - a function" and predicting the functions of new proteins based on amino acid sequences. (Lab. Bioinformation Technologies)
Development of fundamental and applied problems of nanopathology. (Lab. Nanobiotechnology)
Search for new molecular targets pharmacological regulation of pathological processes for diseases of the central nervous system and hearth-vascular system (lab. biochemistry of amines and cyclic nucleotides)
Development of experimental and computational approaches for rational designing of drugs and the creation of drug nanocompositions and nanocarities (lab. Phospholipid nanoparticles and transport systems)
Study of molecular genetic and biochemical mechanisms for neoplastic transformation and tumor progression, new molecular markers for diagnosis (lab. Biosynthesis of amines)
Themes of IBMX RAMS within the framework of the RAMN program "Nanotechnology and nanomaterials in medicine for the period 2008-2015":
Development of technologies for determining ultra-low concentrations of molecules using molecular detectors (labo. Nanobiotechnology)
Development of medical diagnostic systems based on atomic force microscopy and nation-conductive materials (lab. Nanobiotechnology)
Study of new drugs equipped with a passport system based on phospholipid nanoparticles (labo. Phospholipid nanoparticles and transport systems)

In IBMX, medical and biological research is carried out in the following areas:

• Identification of biomarkers for predicting the risks and early diagnosis of socially significant diseases using post-generic technologies (personalized medicine)
• Development of molecular detectors, reagents, algorithms and laboratory protocols to create new methods of medical diagnostics
• Search for molecular targets, design and research of physiologically active substances, the creation of drug transport systems

Department of Bioinformatics:

The Bioinformatics Department IBMX conducts research in the field of bioinformatics and computer design of drugs. The presence of qualified specialists, original and commercially available software and databases, as well as high-performance computing resources allows for fundamental research and applied developments covering the entire chain "from genomes to medicine in Silico".

The IBMX bioinformatics department currently includes five laboratories:

Bioinformational technologies (Head - Corresponding Member RAS, D. B.N. Andrei Valerievich Lisitsa).

Analysis of postgenis data (head - K.B.N. Elena Alexandrovna Ponomarenko).

Structural and functional design of drugs (head - prof., D.B., K.F.-M.N. Vladimir Vasilyevich Polarov).

Structural bioinformatics (Head - D. B.N. Alexander Vladimirovich Veselovsky).

Parallel computing and information technologies (head. - K.B.N. Owned Stanislavovich Skvortsov).

The Institute was established in 1944 on the basis of biochemistry departments and organic chemistry. First Director of the Institute in 1944-1948 There was an academician Yakub Oscarovich Parnas. Academician Vasily Nikolaevich Orekhovich led the Institute in 1949-1989. Recognition of his merit in the development of the institute was the assignment of the Institute of Biomedical Chemistry of the RAM named after V.N. Orekhovich. Since 1989, the Institute is headed by Academician Alexander Ivanovich Archakov.
In the organization and formation of the institute, the largest scientists of the country's biochemists took part: Academicians A.E. Brownshtein, M.M. Shemyakin, S.E. Severin, V.M. Rodionov, N.A. Yudaev, S.R. Mardashov, T.T. Birch; Correspondent members V.Z. Gorkin, B.F. Korovkin and I.I. Vinnet; Professor S.Ya. Kaplansky, G.L. Rosenfeld, G.Ya. Viderchain, V.S. Tongur, TS Easter, and others. With their names are associated with many significant achievements of domestic biomedical science. In particular, A.E. Brantstein found fundamental data on enzymatic transamination processes and, in collaboration with academician M.M. Shemyakin, created general Theory pyridoxalphosphate-dependent reactions; V.N. Orekhovich with sob. Characterized proliteindopeptidase (Eph 3.4.22.18), Cathepsin R (CF 3.4.99.33) and Dipeptidylcarboxypeptidase (angiotensin surgery enzyme, CF 3.4.15.1); prof. I.S. Severin was obtained fundamental results on deciphering the mechanism for regulating the activity of aspartattransaminase - the most important enzyme of nitrogen exchange.
A.I. Archakov is one of the world's leading specialists in the field of microsomal oxidation. His work has made a significant contribution to deciphering the structural and functional relations between the membrane proteins of the US cytochromes of P450 and in understanding the general mechanisms of intermolecular recognition. Results of scientific research obtained by A.A. Archakov with Sotr., Public Prizes were awarded: USSR, RSFSR and the Russian Federation.
As of January 1, 2004, 210 people operate at the Institute, including 122 researchers, including 3 academicians of RAMS, 7 professors, 26 doctors and 66 candidates of science.
The structure of the institute contains the department of proteoma studies, nine scientific laboratories, academic group of academician RAMS T.T. Berezov, Scientific and Production Department and Advisory Diagnostic Polyclinic.
The Institute occupies a leading position in the country in such modern areas of biomedical research as:
- proteomics;
- bioinformatics;
- Nanobiotechnology.
Research and Developments are held by the Institute within the framework of projects of international scientific funds (ISTC, Intas, CRDF, Wellcome Trust, JanSsen Research Foundation, Royal Society, etc.), Russian Foundation for Fundamental Studies, Russian Academy of Medical Sciences, Ministry of Health of the Russian Federation, Ministry of Industry, Science and technology of the Russian Federation, the Moscow Committee on Science and Technology, as well as agreements and agreements on cooperation with various organizations.
In 2001, on the basis of the Institute, the First In Russia, the Center for Proteomed Research, which works as part of the interdepartmental scientific and technological program "Proteomika for Medicine and Biotechnology", and a number of projects supported by the Ministry of Industry of the Russian Federation, the Ministry of Health of Russia and the RAMS. Protomational studies are associated with the inventory and study of post-translation modifications of proteins with the help of combined use of methods: two-dimensional electrophoresis, chromatography, mass spectrometric analysis of proteolytic fragments of proteins. Applied Studies are aimed at developing methods for diagnosing hepatitis and tumors, a study of industrially significant microorganisms, etc.
Methods 2D-Page, Maldi-Tof mass spectrometry and separation on chromatographic chip SELDI found that the alpha chain of the Haptoglobin, Apolipoprotein A-I, A-IV, Orosomukoids are statistically reliable ovarian cancer markers, and sulfated glycoprotein - breast cancer marker. The methods of analysis of membrane proteins developed in the department allowed us to obtain a proteoma card of microsomal liver proteins reflecting the change in protein expression during their medicinal induction. In order to study the variability of Helicobacter pylori strains, proteoma typing of isolates from different regions of Russia was carried out.
The employees of the proteomal department have developed computer programs and databases for analyzing complex mass spectra and to identify marker proteins on proteoma maps, as well as educational program In the course of proteomics to improve the qualifications of researchers working in the field of biochemistry and molecular biology.
Works in the field of bioinformatics are aimed at creating an integral platform covering the entire study chain "from genomes to medicine in Silico", which solves the following tasks: (1) identification of macromolecule-target based on genomic and proteomatic data; (2) Validation of targeted by targets with computer and experimental methods; (3) identifying the most promising basic structures of new drugs; (4) Optimization of basic drug structures. The basic structures of new drugs identified using bioinformatics methods are tested in in vitro and in vivo experiments. The practical result of these studies was: identifying the most promising targets to create medicines against Mycobacterium tuberculosis; Selection of immunogenic peptides in the hepatitis C virus polyprotein for creating vaccine structures; constructing new high-selective monoaminoxidase inhibitors A as potential antidepressants; The discovery of original anxiolyts and nootrops with a high degree of novelty of the chemical structure, detection of antihypertensive substances with combined mechanisms of action, etc. The Institute develops nanobiotechnological approaches that have several orders of magnitude more sensitivity and speed compared to currently used standard methods Analysis. These include methods based on the use of optical nanostructured biosensors conjugate with mass spectrometers, atomic force microscopes, which make it possible to detect, concentrate and identify functional and significant biomacomolecules in biological fluidsin a wide range of concentrations (from micro-to-atomol).
Every year, 50-80 scientific articles in domestic and international scientific journals are published annually; Over the past decade, 19 Russian and 2 international patents were obtained.
Developed and introduced into medical practice new drug Treatment For the treatment of chronic liver diseases of different etiologies phosphogle (capsule and injection form). In order to organize the production of this drug at the Institute, a building was reconstructed and a production site was organized.
On the basis of the Institute, the Ramna Scientific Council and the Ministry of Health of the Russian Federation for Biomedical Chemistry, which takes part in the work of 11 research organizations.
The Institute has a training system for training through co-investment and graduate school with a specialty "Biochemistry"; The dissertation council on the protection of dissertations for the degree of doctor and the candidate of biological and medical sciences in the specialty "Biochemistry" is working. Over the past decade, 8 doctoral and 52 candidate dissertations were defended.
The Institute is an educational basis for students, diploman and graduate students from IBF RGMU, MMA them. THEM. Sechenov, MEPI, MIPT and other universities in Moscow, which perform coursework, diploma and dissertation work here using post -genomic technologies. Institute staff take part in reading lectures and conducting seminars for IBF Students RGMU, MGSA and MAPP.
On the basis of the Institute, the Scientific Journal of Biomedical Chemistry (ISSN 0042-8809) is published, which publishes work on all modern sections of biological and medical chemistry.
IN last years Scientific achievements of the State University of BMX RAMN Awards: The State Prize of the Russian Federation in the field of science and technology for 1998 for the work "Microsomal oxidation and metabolism of drugs: the mechanism of oxygenase reactions catalyzed by cytochrome R450, and their modeling", the Government Prize of the Russian Federation in the region Science and technology for 2002 for the creation of a domestic drug for the treatment of phosphogli liver disease, two premiums of the Presidium of the RAM for the results in the field of fundamental medical research.
Keeping the traditions of the domestic scientific school laid by academics RAMS Ya.O. Parnas, V.N. Orekhovich, A.I. Archakov, and developing international scientific cooperation, the institute is today one of the leading centers of biomedical science in Russia.

Wikipedia material - free encyclopedia

Institute of Biomedicine Chemistry named after V. N. Orekhovich Ramna (IBM RAS)
Based
Director	Andrei Valerevich Lisitsa
Employees	270 people, including 178 scientists
Graduate school
Location
Legal address	History IN different time At the Institute, academician academician academician scientists worked, M. M. Shemyakin, S. E. Severin, N. A. Yudaev, S. R. Mardashev, T. T. Berezov; Correspondent members V. Z. Gorkin, B. F. Korowkin and I. I. Vinin; Professor S. Ya. Kaplansky, G. L. Rosenfeld, G. Ya. Viderchain, V. S. Tongur, T. S. Peskina. Field of scientific research proteomics; Protomational studies are associated with the study of post-translation modifications of proteins. bioinformatics; Bioinformatics covers research from genomes to medicine and solves problems: identification of target macromolecules based on genomic and data; Synthesis of new drugs. nanobiotechnology. Nanobiotechnology use nanostructured biosensors to determine functional and significant biomacomolecules in biological fluids. The Institute has developed a drug phosphoglie, intended for the treatment of chronic liver diseases. Structure of the Institute The Institute includes the departments of proteoma studies and mass spectrometry, personalized medicine, nanolas, bioinformatics, scientific laboratories of protein biosynthesis, peptide engineering, microsomal oxidation, etc. Modernity Currently, the Institute is working in areas: the use of biomarkers for early diagnosis of diseases, the development of molecular detectors, reagents for new methods of diagnosing diseases, the creation of drug transport systems in the human body. Proceedings The scientific works of the Institute staff are printed in the published Institute of the Journal "Biomedical Chemistry" (until 2003 - "Issues of Medical Chemistry"). Write a review of the article "Institute of Biomedicine Chemistry named after V. N. Orekhovich" Links Notes Coordinates: 55 ° 43'57 "p. sh. 37 ° 34'03 "s. d. /  55.73250 ° С. sh. 37.56750 ° C. d./ 55.73250; -37.56750 (G) (I) An excerpt characterizing the Institute of Biomedical Chemistry named after V. N. Owankovich - I listen, your Excellency, - Timokhin said, giving a smile to feel that he understands the desires of the chief. - Yes Yes. The regimental commander found in the ranks of Dologov and held a horse. "To the first case - Eps," he said to him. She looked back, did not say anything and did not change the expressions of his mockingly smiling mouth. "Well, that's good," continued the regimental commander. - People in the charm vodka from me, - he added so that the soldiers heard. - Thank you all! Thank God! - And he, overtaking the company, drove up to another. - Well, he, right, good man; It is possible to serve with him, "said Timokhin Subountern to the officer who goes beside him. "One word, Chervoy! ... (The regimental commander called the Chervon King) - Laughing, said SubaLental officer. The happy arrangement of the spirit of the authorities after the view passed and to the soldiers. Rota walked fun. From all sides, soldier's voice spoken. - How did you say Kutuzov curve, about one eye? - Oh no! Almost curve. - Not ... Brother, Eye to you. Boots and exposure - everything looked around ... - Like him, brother you are, I look at my feet ... well! I think ... "And the other then Austria, he was, as if chalk smeared." Like flour, white. I am tea, how the ammunition is clean! - What, Fedeshow! ... did he say, or if the defendants begin, were you closer? Everything spoke, in Brunov, Bunapart himself stands. - Bunaparta stands! You are lying, fool! What does not know! Now Prussac Bunutuet. Austria Him, it means, satisfies. As he gets shaken, then with Bunaro war will open. And then, says, in Brunov, Bunapartes stands! It is clear that the fool. You listen more. - Vish the devils of the apartments! The fifth company, looked, worst into the village, they boil porridge, and we will not reach the place before. - Give Sukharik, Chort. - And tobacco then gave yesterday? That brother. Well, on, God is with you. - At least I would have done, and then there is no verst five from the bottom. - that way there was like the Germans of the strollers applied to us. Going, know: important! - And here, the brother, the people are completely frantic. Everything is as if the Pole was, the whole Russian crown; And now, brother, a solid German went. - Songns forward! - I was heard the cry of the captain. And before the company, twenty people ran out from different ranks. The drummer fought turned his face to the songwriters, and, having waved his hand, dragged the outstanding soldier's song, which began: "Does not be loaded, the sun is engaged ..." and ending with the words: "That, brothers, will be glory to us with a Kamensky father ..." This song has been folded Now in Turkey, now in Austria, only with the change that words are inserted into the place of Kamensky Father: "Kutuzov Father." Tinging the soldiers of these last words and waving his hands, as if he threw something on the ground, the drummer, a dry and beautiful soldier of forty years, strictly looked at the songwriters and clogged. Then, making sure that all the eyes are directed to him, he seemed to carefully lifted some kind of invisible, the precious thing over his head, he held it so a few seconds and suddenly desperately threw her: Oh, you, Seni My, Seni! "Songy new my ...", picked up twenty votes, and a spider, despite the severity of the ammunition, jerkingly joined the forward and went back in front of his mouth, move his shoulders and threatening someone to spoons. Soldiers, in the ranks of songs waving their hands, went to a spacious step, unwittingly falling down. From behind the company heard the sounds of the wheels, pummage of the spring and the horses horses. Kutuzov with a retinue returned to the city. The commander-in-chief made a sign so that people continue to go outbreak, and on his face and on all persons, his suits were a pleasure at the sounds of songs, at the sight of a dying soldier and fun and boyko walking company soldiers. In the second row, from the right flank, from which the stroller overtook the company, the blue-eyed soldiers rushed into the eyes, Shahov, who especially Boyko and gracefully walked into the ranks of the songs and looked at the faces passing with such an expression, as if he regretted everyone who did not go At this time with a roth. The Gusar Kornet from Kutuzov's Sweets, who had an opposing regimental commander, lagged behind the stroller and drove to Dolohov.